https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50249 Wed 28 Feb 2024 16:16:46 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7209 Wed 11 Apr 2018 16:54:03 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15692 $1,000 acceptable as reward for quitting smoking. Conclusions: Acceptability for the use of financial incentives in reducing antenatal smoking is low among pregnant women. Future research should explore views of a wider audience and continue to gather stronger evidence of the efficacy of rewards for reducing smoking in pregnancy.]]> Wed 11 Apr 2018 16:49:51 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6849 Wed 11 Apr 2018 16:39:01 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:15676 Wed 11 Apr 2018 14:24:58 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:6851 Wed 11 Apr 2018 10:50:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4378 A, causes overexpression and supports uncontrollable cellular growth. This polymorphism has been associated with an increased risk of developing many cancers, including endometrial cancer. Methods: The 870 G>A polymorphisms (rs605965) in the cyclin D1 gene was genotyped in an Australian endometrial cancer case-control population including 191 cases and 291 controls using real-time PCR analysis. Genotype analysis was performed using chi-squared (χ²) statistics and odds ratios were calculated using unconditional logistic regression, adjusting for potential endometrial cancer risk factors. Results: Women homozygous for the variant cyclin D1 870 AA genotype showed a trend for an increased risk of developing endometrial cancer compared to those with the wild-type GG genotype, however this result was not statistically significant (OR 1.692 95% CI (0.939-3.049), p = 0.080). Moreover, the 870 G>A polymorphism was significantly associated with family history of colorectal cancer. Endometrial cancer patients with the homozygous variant AA genotype had a higher frequency of family members with colorectal cancer in comparison to endometrial cancer patients with the GG and combination of GG and GA genotypes (GG versus AA; OR 2.951, 95% CI (1.026-8.491), p = 0.045, and GG+GA versus AA; OR 2.265, 95% CI (1.048-4.894), p = 0.038, respectively). Conclusion: These results suggest that the cyclin D1 870 G>A polymorphism is possibly involved in the development of endometrial cancer. A more complex relationship was observed between this polymorphism and familial colorectal cancer.]]> Wed 11 Apr 2018 10:44:26 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:13926 Wed 11 Apr 2018 09:52:21 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9714 Wed 11 Apr 2018 09:43:06 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:37483 Wed 08 May 2024 11:18:17 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:36133 Thu 28 Oct 2021 12:36:52 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50897 Thu 10 Aug 2023 12:35:56 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:7378 Sat 24 Mar 2018 08:40:13 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:9354 Sat 24 Mar 2018 08:36:33 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:21378 Chlamydia trachomatis infection is increased by oral contraceptives and modulated by sex hormones. We therefore sought to determine the effects of female sex hormones on the innate immune response to C. trachomatis infection. Method of study: ECC-1 endometrial cells, pre-treated with oestradiol or progesterone, were infected with C. trachomatis and the host transcriptome analysed by Illumina Sentrix HumanRef-8 microarray. Primary endocervical epithelial cells, prepared at either the proliferative or secretory phase of the menstrual cycle, were infected with C. trachomatis and cytokine gene expression determined by quantitative RT-PCR analysis. Results: Chlamydia trachomatis yield from progesterone-primed ECC-1 cells was significantly reduced compared with oestradiol-treated cells. Genes upregulated in progesterone-treated and Chlamydia-infected cells only included multiple CC and CXC chemokines, IL-17C, IL-29, IL-32, TNF-α, DEFB4B, LCN2, S100A7-9, ITGAM, NOD2, JAK1, IL-6ST, type I and II interferon receptors, numerous interferon-stimulated genes and STAT6. CXCL10, CXCL11, CX₃CL1 and IL-17C, which were also upregulated in infected secretory-stage primary cells, and there was a trend towards higher levels of immune mediators in infected secretory-phase compared with proliferative-phase cells. Conclusion: Progesterone treatment primes multiple innate immune pathways in hormone-responsive epithelial cells that could potentially increase resistance to chlamydial infection.]]> Sat 24 Mar 2018 08:04:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:30047 Sat 24 Mar 2018 07:31:23 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:4903 Sat 24 Mar 2018 07:22:59 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:23163 80% of LLETZ procedures be performed under local anaesthesia. There is a paucity of clinical data regarding both the proportion of women receiving general anaesthesia for treatment, factors underpinning this choice and the impact of mode of anaesthesia on treatment outcomes. Aims: To identify the proportion of women who have a LLETZ under general anaesthesia and to establish the impact of mode of anaesthesia on outcomes including treatment efficacy, overtreatment (negative histology), short-term morbidity and attendance for follow-up. Methods: Single-centre retrospective analysis of all women treated with LLETZ for suspected cervical dysplasia between 1, May 2005 and 1, May 2009. Results: Thirty-three percent of a total 465 LLETZ procedures were carried out under general anaesthesia, although the reason for anaesthesia choice was not recorded in 52% of cases. There were no significant differences in the primary outcomes of unclear LLETZ margins or negative LLETZ histology, or in the secondary outcomes of depth and surface area of LLETZ specimen, short-term morbidity or rates of incomplete follow-up. Conclusions: Although reasons underpinning selection of anaesthesia mode remain elusive, at this centre, outcomes following LLETZ procedure for the management of suspected cervical dysplasia are not affected by the mode of anaesthesia used.]]> Sat 24 Mar 2018 07:10:30 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44743 Mon 24 Oct 2022 08:35:57 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50984 Mon 14 Aug 2023 15:52:49 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51418 Mon 04 Sep 2023 14:57:16 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50983 Mon 01 Jul 2024 10:25:10 AEST ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:34930 Fri 10 Mar 2023 18:38:15 AEDT ]]>